Chronic Effects of Ziprasidone, Aripiprazole, Blonanserin, Cyamemazine, and Nemonapride on Mice Isolated Detrusor Smooth Muscle

Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify effects these in mice isolated bladder using organ bath systemMaterials Methods: The were injected intraperitoneally with 21 days. investigated on isoproterenol-induced relaxation responses carbachol-induced contractions detrusor strips. strips stimulated KCl, then tissues washed a further 30 min precontracted submaximal concentration carbachol. After contraction reached plateau, cumulative concentration-response curves isoproterenol obtained.Results: We showed that dose-dependently relaxed by obtained from ziprasidone, cyamemazine but not treated group. However, none drug treatments had any effect KCl mice's bladder.Conclusion: increased relaxations smooth muscle indicates it can increase capacity. demonstrate four may represent potential overactive bladder. They might be clinically useful patients should use antipsychotics.